The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response
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منابع مشابه
The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response.
Invasive nontyphoidal Salmonella (NTS), including Salmonella typhimurium (STm), are major yet poorly-recognized killers of infants in sub-Saharan Africa. Death in these children is usually associated with bacteremia, commonly in the absence of gastrointestinal symptoms. Evidence from humans and animal studies suggest that severe infection and bacteremia occur when specific Ab is lacking. Unders...
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In mice, the IgG subclass induced after Ag encounter can reflect the nature of the Ag. Th2 Ags such as alum-precipitated proteins and helminths induce IgG1, whereas Th1 Ags, such as Salmonella Typhimurium, predominantly induce IgG2a. The contribution of different IgG isotypes to protection against bacteria such as S. Typhimurium is unclear, although as IgG2a is induced by natural infection, it ...
متن کاملParticipation of the Salmonella OmpD Porin in the Infection of RAW264.7 Macrophages and BALB/c Mice
Salmonella Typhimurium is the etiological agent of gastroenteritis in humans and enteric fever in mice. Inside these hosts, Salmonella must overcome hostile conditions to develop a successful infection, a process in which the levels of porins may be critical. Herein, the role of the Salmonella Typhimurium porin OmpD in the infection process was assessed for adherence, invasion and proliferation...
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An ompD mutation caused by a Tn10 insertion was transduced into Salmonella typhimurium SL1344 and UK-1. The adherence and invasion capabilities of the resultant ompD mutants were examined by tissue culture analysis. The virulence of the S. typhimurium ompD mutants was ascertained by a 50% lethal dose (LD50) study and by determining colonization ability with BALB/c mice. We found no statisticall...
متن کاملThe capsular polysaccharide Vi from Salmonella typhi is a B1b antigen.
Vaccination with purified capsular polysaccharide Vi Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy is not clearly established. In this study, we have characterized the B cell response to this vaccine in wild-type and T cell-deficient mice. We show that immunization with typhoid Vi polysaccharide vaccine rapidly induces proliferation in B1b p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0812431106